Endocrine Abstracts

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is a complex autosomal dominant inherited syndrome characterized by medullary thyroid carcinoma (MTC), phaeochromocytoma, and primary parathyroid hyperplasia (PPH). In patients with only one or two clinical features, identification of a germline rearranged in transfection (RET) mutation or the identification of the clinical features of MEN2A in other first degree relatives is required to make the diagnosis. We present ...

Introduction: Gestational diabetes mellitus (GDM) is a sort of temporary carbonhydrate intolerance in pregnancy. GDM leads to a variety of risks for the fetus and the mother during pregnancy. Mothers who had GDM during their pregnancy have high risk of caesarean section and pre-eclampsia. Also there are risks of macrosomia, neonatal hypoglycemia and hyperbilirubinemia for the fetuses of these mothers. Cardiovascular disorders, hypertension, dyslipidemia and metabolic syndrome ...

Introduction: Isotretinoin (Iso) treatment in acne disease may cause dyslipidemia and increased liver enzymes. Its effects on lipid and glucose metabolism may cause atherogenic complications. The aim of this study was to evaluate carotis intima–media thickness (CIMT), HOMA-IR, and osteopontin (OPN) levels in acne patients on Iso treatment.Methods: Iso treatment given 21 patients are included in this study. They followed for 4 months. 21 patients wit...

Introduction: Resecting a pheochromocytoma is a high-risk surgical procedure, life threatening complications may occur. In this presentation, we reported a case of resistance hypotension after pheochromocytoma resection.Case: A 70-year-old male with a history of prostate adenocarcinoma admitted to urology policlinic for cancer screening. Abdominal ultrasound revealed 6.5×5.5 cm mass in left adrenal gland and patient referred to endocrinology policli...

Introduction: Graves’ disease and toxic multinodular goiter are known to have different etiologies and pathogenesis, which are not fully comprehended today. This study compares the protein profiles of Graves’ disease and toxic multinodular goiter patients’ thyroid samples using proteomics methods and investigates the role of differentiating proteins in the pathogenesis of these diseases.Methods and Design: Difference Gel Electrophoresis (D...

Background: Adrenocortical carcinoma (ACC) is a rare cancer that originates from the cortex of the adrenal gland. Although its exact etiology is not clear, it has been found to be associated with some hereditary cancer syndromes. Sometimes patients present with hormonal excess symptoms (virilization, Cushing’s syndrome) or local symptoms consistent with an abdominal mass. In ACC, computed tomography (CT) and magnetic resonance imaging (MRI) are preferred imaging modaliti...

Introduction: Wolfram syndrome, is a rare autosomal recessive genetic disorder that is characterized by diabetes mellitus (DM), diabetes insipidus (DI), optic atrophy, and sensorineural deafness as well as various other possible disorders. DM is the first manifestation, and optic atrophy also onsets in the first decade of life. The onsets of DI and sensorineural deafness are in the second decade, urinary tract abnormalities are in the third decade, and neurologic abnormalities...

Objective: To report a rare cause of ectopic adrenocorticotropic hormone (ACTH) secretion leading to Cushing syndrome.Methods: We describe the clinical presentation and management of a case of Cushing syndrome attributable to ectopic ACTH secretion from small cell cancer of the prostate.Results: In a 74-year-old man developed hypocalemia and heart failure. He was found to have severe hypokalemia (serum potassium, 2.37 mEq/l). Hormo...

Background: Currently, multiple treatment options are available for the treatment of acromegaly. However, cure is obtained only in 50% of patients with macroadenomas after surgery. Persistent tumor enlargement occur in 2.2% of the patients treated with somatostatin analogs and in 1.6–2.9% of the patients treated with pegvisomant. The nuclear antigen Ki-67 is related to growth potential and is also a major prognostic indicator for pituitary adenomas. Studies demonstrated t...

Background: Currently, no effective medical treatment exists for recurrent and aggressive craniopharyngiomas that are resistant to conventional therapies, including repeat surgeries and adjuvant radiotherapy (RT). Temozolomide is an alkylating chemotherapeutic agent and is used routinely in the management of high grade gliomas. The response to temozolomide is suggested to be dependent on the tumoral expression of O-6 methylguanine DNA methyltransferase (MGMT). Evidence ...